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Spic gene

WebOct 1, 2002 · Gene names Name SPIC Organism names Organism Homo sapiens (Human) Taxonomic identifier 9606 NCBI Taxonomic lineage Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo Accessions Primary accession Q8N5J4 … WebNov 25, 2015 · In the spleen, haem drives SPIC expression, which controls the differentiation and maintenance of red pulp macrophages and the expression of key splenic red pulp macrophage-specific molecules,...

Role for Spi-C in the development of red pulp …

WebJul 22, 2010 · The SPI1 gene, also known as PU.1, encodes a member of the E26-transformation-specific family of transcription factors and is expressed specifically in cells of the hematopoietic lineage. 1 SPI1/PU.1 transcription factor activity is crucial for development of cells of the myeloid and lymphoid lineages. 2-7 PU.1-null mice lack … WebSpi-C was encoded by a single-copy gene that was mapped to chromosome 10, region C. Spi-C interacted with DNA similarly to PU.1 as judged by methylation interference, band-shift and site selection analysis, and activated transcription of a kappaY element reporter gene upon co-transfection of HeLa cells [6]. great hearts irving powerschool https://mimounted.com

Salmonella enteritidis double knockout attenuated mutant and ...

Web013039 129S- Spic tm1Kmm /J In these mutant mice a loxP -flanked neomycin resistance (neo) cassette replaces exons 2-5 of the Spi-C transcription factor (Spi-1/PU.1 related) gene ( Spic ), abolishing gene function. These mice may be useful for studying the development and function of red pulp macrophages. WebNov 6, 2024 · SPIC Spi-C transcription factor Gene ID: 121599, updated on 6-Nov-2024 Gene type: protein coding Also known as: SPI-C See all available tests in GTR for this gene Go to complete Gene record for SPIC Go to Variation Viewer for SPIC variants Summary float forward emdr

Controversy Surrounding the Function of SpiC Protein in

Category:SPIC Gene - Somatic Mutations in Cancer - Wellcome Sanger …

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Spic gene

Role for Spi-C in the development of red pulp …

WebThe salmonella enteritidis double knockout attenuated mutant is obtained by knocking out crp gene and spiC gene of salmonella enteritidis C50041. The invention further discloses a preparation... WebIn these mutant mice a loxP -flanked neomycin resistance (neo) cassette replaces exons 2-5 of the Spi-C transcription factor (Spi-1/PU.1 related) gene ( Spic ), abolishing gene function. These mice may be useful for studying the development and function of red pulp macrophages. Something went wrong Network Error How it's Made How it's Used

Spic gene

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WebSPIC has 1,374 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 48 datasets. WebMay 26, 2005 · Transcription of the spiC gene is controlled by PhoP/PhoQ two-component system via the SpiR/SsrB system. Genetic organization of the spiR, ssrB, spiC, spiA and spiB genes in the SPI-2 pathogenicity island. The PhoP/PhoQ two-component system regulates transcription of the ssrB gene by the PhoP protein binding to the ssrB promoter. PhoP …

WebMar 21, 2024 · SPIC (Spi-C Transcription Factor) is a Protein Coding gene. Diseases associated with SPIC include Cauda Equina Syndrome . Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding … WebFeb 9, 2024 · Add to Cart. Spigen Tempered Camera Lens Screen Protector [GlasTR Optik] designed for Galaxy S22 / Gal…. $12.99. Add to Cart. Spigen [USB-IF Certified USB 4 Cable 2.6ft for Thunderbolt 4 3 Cable,100W Charging 40Gbps…. $24.99. Add to Cart. Spigen USB C Car Charger, 65W Dual USB Car Charger Fast Charge (PD 3.0 45W + 2…. $31.99.

WebThere is a very high volume of traffic coming from your site (IP address 40.79.131.210) as of Sat Apr 15 06:04:48 2024 (California time). So that other users get a fair share of our bandwidth, we are putting in a delay of 10.0 seconds before we service your request. WebDescription: Homo sapiens Spi-C transcription factor (SPIC), mRNA. (from RefSeq NM_152323) RefSeq Summary (NM_152323): The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]. Gencode Transcript: …

WebJan 15, 2009 · Spic (-/-) mice have a cell-autonomous defect in the development of red pulp macrophages that is corrected by retroviral Spi-C expression in bone marrow cells, but have normal monocyte and other macrophage subsets. Red pulp macrophages highly express genes involved in capturing circulating haemoglobin and in iron regulation.

WebPanel Description. Sequence variants and/or copy number variants (deletions/duplications) within the SPIC gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported. Benign and likely benign variants are generally not reported. float fort mcmurrayWebNov 28, 2013 · In this study, we constructed two gene deletion mutants, Sdu189Δ spiC and Sdu189Δ spiC Δ aroA , with the parental strain S . Dublin Sdu189. The immunogenicity and protective efficacy were ... float for water troughWebSpiC is a virulence factor encoded within Salmonella pathogenicity island 2 (SPI-2). We have previously reported that infection of macrophages with Salmonella enterica serovar Typhimurium results in the SPI-2-dependent activation of the mitogen-activated protein kinase (MAPK) signalling pathways, leading to the expression of suppressor of ... float forward yogaWebGene: Spic Location: Chr10:88511131-88518885 bp, - strand Genetic Position: Chr10, 44.14 cM, cytoband C Alliance: Spic tm1(EGFP/cre/ERT2)Wtsi page Mutation origin: Mutant Cell Line: CEPD0063_4_A10: Germline Transmission: Earliest citation of germline transmission: J:204812: Parent ... float foundation minneapolisWebAug 29, 2005 · Transcriptional analysis of Salmonella exposed to NO generated chemically or synthesized enzymatically by activated macrophages has revealed that nitrogen oxides inhibit overall transcription of SPI2 genes, including the effectors sspH2, srfJ, and sifA that are encoded outside the SPI2 gene cluster. float for sump pump switchWebAug 7, 2024 · SpiC was the first SPI2-encoded protein to be identified that could be secreted by the Spi/Ssa T3SS2 system into the macrophage cytoplasm ( Ochman et al., 1996; Uchiya et al., 1999 ). A spiC -deletion mutant had significantly reduced virulence in mice. float frames for paintingsWebDescription: Homo sapiens Spi-C transcription factor (SPIC), mRNA. (from RefSeq NM_152323) RefSeq Summary (NM_152323): The protein encoded by this gene regulates the development of red pulp macrophages, which are necessary for iron homeostasis and the recycling of red blood cells. [provided by RefSeq, Aug 2016]. Gencode Transcript: … float frames for canvas prints