WebAug 30, 2024 · Uncoupling of mitochondrial respiration by chemical uncouplers has proven effective in ameliorating obesity, insulin resistance, and hyperglycemia. However, development of uncoupler-based therapy remains challenging due to its potentially lethal adverse effects. Here, we identify pyruvate dehydrogenase (PDH) as a key modifier of … Web"United States Patent WO/2024/108739 Chemical uncouplers of respiration and methods of use thereof", Dana-Farber Cancer Institute Inc, Jun 6, 2024 • Spiegelman BM, Long JZ. "United States Patent WO2024075329A2 Methods for identification, assessment, prevention, and treatment of metabolic disorders using
Therapeutic potential of mitochondrial uncouplers for the treatment …
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Theodore Kamenecka Inventions, Patents and Patent Applications
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